Gender is a socially constructed term that categorizes people by real or perceived physical/sexual characteristics. The word transgender is a relatively new term that encompasses a multitude of gender identities and expressions inclusive of those identities and expressions that most closely resemble the eunuchs we read about in the Bible.
Eunuchs are people who, for various reasons, live a different kind of sexual reality. Some eunuchs are that way because they are born with ambiguous genitalia. Some eunuchs undergo genital modification and are made eunuchs by others. Some eunuchs make the conscious choice to alter their own physical realities out of a desire to live more congruently with a higher reality.
In Isaiah 56, the prophet lays out the terms and conditions for living in covenant with God. He begins the chapter by saying that to choose what is right brings pleasure to God. In verse 4, the prophet says that even the stranger and the eunuch, who were traditionally looked down upon by the people of Israel, are free to live in covenant with God. In verse 5, the prophet proclaims that God’s way of righteousness and covenant is extended to all and their reward will be their reputation and legacy.